The difference between highly sensitive and hypersensitive. Free flashcards to help memorize facts about bio 270 practice. In particular tcell mediated delayedtype hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Also it was reported that buccal aspect of cervical area is the commonly affected site 18. Dentin hypersensitivity as a chronic disease is increasingly prevalent among adults and some researches has been done on determining etiologic factors in causation of the disease, its diagnosis and its treatment 1, 6. The status of the pulp in dentin hypersensitivity is not known, although symptoms would suggest it unlikely that there is an acute or chronic inflammation due to the length of time symptoms persist. Gain an understanding of what causes the four classic types of hypersensitivity reactions in the skin and how to recognize them. Learn hypersensitivity types with free interactive flashcards. To investigate the efficacy of an occluding dentifrice in. Which of the following is a pattern of behavior characterized by compulsive drug use as evidenced in overwhelming involvement with the use of a drug, obtaining an adequate supply of it, and a strong tendency in resuming use of it after stopping for a period. All of these terms convey the same clinical conception and can be used interchangeably table 1. Mar 20, 2020 this article gives you a clear structure of hypersensitivity and its types. Pdf in one form or the other, pain is the major reason for patients to visit the dentist.
The most widely accepted theory for dentinal hypersensitivity is the. Outline the mechanisms by which ige, antibodies, immune complexes and t cells can cause tissue damage and inflammation the four types of hypersensitivity, giving examples of the clinical syndromes associated with each. These consensus recommendations for the diagnosis and management of dentin hypersensitivity were developed by a broadly constituted board of dentists and dental hygienists drawn from general dental practice, specialist practice, academia and research from across canada, joined by 2 international dentists with subject matter expertise. The difference between highly sensitive and hypersensitive high sensitivity is biological. Substance abuse midterm substance abuse studies cju 350. Pdf treatment of dentine hypersensitivity by lasers. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests. Etiology of dentine hypersensitivity dentin is covered by enamel in the crown region and by cementum in the radicular region. Introduction dentinal hypersensitivity dh is characterized by short sharp pain arising from exposed dentine in response to stimuli typically thermal, evaporative, tactile, osmotic or chemical and which cannot be ascribed to. Hypersensitivity refers to undesirable damaging, discomfort producing and sometimes fatal reactions produced by the normal immune system.
While sobbing at the drop of a hat is known to be a key indicator of someone who is highly emotional, there are other notsosubtle signs that youre a hypersensitive person. Hypersensitivity and idiosyncratic reactions to oxaliplatin. The normal immune response, overview on hypersensitivity, types of hypersensitivity. Newman department of physiology, uniuersity of minnesota, minnapolis, mn 55455 key words glial cell, intracellular ph, carbon dioxide regulation, retina abstract carbonic anhydrase activity was characterized in freshly dissociated muller cells of the salamander retina. Hay fever, asthma, eczema, bee stings, food allergies. Aetiology, symptoms and theories of pain production. Delayed type hypersensitivity definition of delayed type. Hydrodynamic theory for sensitive dentine was first proposed by brannstorm 21. Lima ms, coletta en, ferreira rg, jasinowodolinski d, arakaki js, rodrigues sc, rocha na, pereira ca. Jul 03, 2011 hypersensitivity reactions lecture notes 1.
Type i hypersensitivity classic allergy mediated by ige attached to mast cells. Hypersensitivity reactions a state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign agent. Hypersensitivity reactions require a presensitized immune state of the host. Choose from 500 different sets of hypersensitivity types flashcards on quizlet.
The findings indicate that the intraoral distribution of recession, sensitivity and plaque in this selected population is complex, being partly fitted by a maineffects model, and suggest that tooth cleaning is one of several major factors which influence the occurrence and distribution of dentine hypersensitivity. Hypersensitivity reactions lecture notes slideshare. A physiological measure of carbonic anhydrase in muller cells. Glial cell regulation of extracellular potassium 5 rnv 25 ms 725 fig. Consensusbased recommendations for the diagnosis and. Hypersensitivity reactions when our immune system gets mad there are 4 types of hypersensitivity reactions, usually labelled in latin numbers. Much of the current opinion on dentin hypersensitivity is based on logical and sensible supposition rather than scientific evidence. Sep 03, 2015 drug hypersensitivity reactions dhr have been present since the advent of drugs. Brannstrom,5 whereby fluid flow within dentinal tubules. Another valid finding was that there was no such as cold. Repetition suppression dissociates spatial frames of. Bibliography hypersensitivity pneumonitis extrinsic. When the enamel or cementum is removed, the underlying dentin will be exposed along with the dentine tubules, producing dentin hypersensitivity. Dentin hypersensitivity etiology, treatment possibilities and other related factors.
A physiological measure of carbonic anhydrase in muller cells eric a. Hypersensitivity reactions can be divided into four types. Identify common differential diagnoses for type i through iv hypersensitivity reactions in the. Table 1 common terms which are used refer to dentin hypersensitivity dentin hypersensitivity sensitivity. Dec 01, 2010 all dental practices have patients with dentin hypersensitivity. Th esy m pt oru l i ngf a c are known as anaphylaxis. Due to differences in populations studied and methods of detection, the reported incidence ranges from 474%. Delayed type hypersensitivity disease model the bioduro advantage bioduros pharmacology team has extensive drug discovery and development experience in the pharmaceutical industry enabling us to support fully integrated programs, including study design and data interpretation. Many patients avoid dental treatment because of the hypersensitivity. Hypersensitivity responses are commonly categorized in four groups type i, type ii, type iii, and type iv later the proposal of gell and coombs in 1963. Before making a diagnosis of dentinal hypersensitivity. The gell and coombs classification of hypersensitivity is the most widely used, and distinguishes four types of immune response which result in bystander tissue damage.
The purpose of this paper is to summarise laser applications for the treatment of dentine hypersensitivity. Etiology and treatment of dentinal hypersensitivity. Oct 05, 2016 to investigate the efficacy of an occluding dentifrice in dentinal hypersensitivity dh the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Describe the prototypic morphologic presentation of the classic type i through iv hypersensitivity reactions in the skin. Immediate type hypersensitivity to gluten like any other food hypersensitivity reaction, gluten hypersensitivity can be divided into immediate or delayed. Surprisingly, most practices do not have a systematic approach for diagnosing and treating this condition. Either igg or igm is made against normal self antigens as a result of a failure in immune tolerance, or a foreign antigen resembling some molecule on the surface of host cells enters the body and igg or igm made against that antigen then cross reacts with the host cell surface. Allergens al er g ns aop i th c stimulate a type i hypersensitivity response. A personal electromagnetic hypersensitivity ehs case study. The exposure of cervical dentine has a multifactorial aetiology and pain may frequently be elicited by a number of stimuli. Dentin hypersensitivity pathogenisis and management.
Classic type iiv hypersensitivity reactions in the skin out. Tcell activation requires clustering of a threshold number of tcell receptors tcrs at the site of antigen presentation, a number that is reduced by cd28 coreceptor recruitment of signalling. This theory is the most widely accepted theory for dh. Dentin hypersensitivityetiology, treatment possibilities. Immunology 1 hypersensitivity and allergy notes 10th february 2011 learning objectives. Several theories try to explain the dentinal hypersensitivity although none of them leads to a thorough understanding of how the stimuli applied in this surface can cause pain. Overview type i type ii type iii type iv common name immediate hyper sensitivity bystander reaction immune complex disease delayedtype hypersensitivity example peanut anaphylaxis pcnassoc. According to this theory, the odontoblast has a special sensory function and the. Dentinal hypersensitivity, dh management, etiology. Hydrodynamic theory is the most commonly agreed upon cause of dentinal hypersensitivity.
Dentine hypersensitivity dhs is a wide spread painful dental problem that is characterized by short sharp pain arising from exposed dentin in response to several different stimuli. The hydrodynamic theory suggests that dentinal pain associ ated with. Hypersensitivity to movement under responsive by denise phila. Hypersensitivity dentinal hypersensitivity can have multiple etiologies. The theories that either the odontoblasts and their processes act as dentinal receptors or the nerves in the pulp are the pain receptors, are discussed. Oxaliplatin is a thirdgeneration platinum analog that is used to treat a variety of solid tumors, particularly colorectal carcinoma. Negative regulation of tcell activation and autoimmunity by.
Dentin hypersensitivity is a relatively common condition. International workshop on electromagnetic field hypersensitivity 2004. Dentists may underreport dentin hypersensitivity due to difficulty in diagnosing and managing the condition. The most widely accepted mechanism of dentin hyper sensitivity is the hydrodynamic theory proposed by. In recent years, dental professionals have grown increasingly aware that dentine hypersensitivity is an. My grandson is 5 years old and appears to be your average 5 year old. Listing a study does not mean it has been evaluated by the u. The immediate hypersensitivity to gluten is igemediated and may become lifethreatening in severe cases when combined with exercise or some medication.